While I wasn't into the last Indy line for its intended purpose I did buy multiples of every figure for custom fodder, and honestly they were truly great despite a few duds and the less than stellar face sculpts on several figures namely Indy's Ford likeness as well as Marion. Though they were great fodder because they didn't look like those two! lol If the figures utilize the photo real method that SW is currently using then that's an immediate improvement from the 2008 line.
So for the same reason I wouldn't necessarily be into another Indy line unless I could use them for potential fodder, thus I would prefer 3.75" scale once again for that reason alone. I would also imagine that it won't be as encompassing as the last line and that it will only offer the main core cast, whoever those characters might be. As for articulation I also feel they will go with the current trend in SW of over complicatedness versus their 08 counterparts, which in some ways will be an improvement while in others maybe not. They were certainly a mix of good and bad choices back then with weird stances for some, yet they were still very well articulated IMO and they also were compatible with the SW figures of 08 which allowed for easy customization.
If they were to venture into a "Classics wave" like the last line did, I wouldn't mind if they formally released those MIA figures like Toht, or rumored/canceled like Walter Donovan. Maybe we could even get Brody, Satipo, Major Eaton etc.